Mesothelioma is a form of cancer which occurs in thin membranes (called the mesothelium) lining the chest, lungs, abdomen and sometimes the heart. Although quite rare, mesothelioma symptoms strike more than 200 people each year in the United States. The majority of mesothelioma cases are directly linked to asbestos exposure.
Because of the long latency period of mesothelioma, the average age of patients is between 50 and 70 years. Mesothelioma affects men most due to the high exposure of asbestos in industrial typed jobs. Mesothelioma symptoms include respiratory problems, shortness of breath, continual cough and pneumonia. Other mesothelioma symptoms include weight loss, abdominal problems and swelling. In some mesothelioma patients, the mesothelioma symptoms are quite muted, making it hard for mesothelioma doctors to diagnose.
Mesothelioma doctors specialize in the study, research, and treatments of Mesothelioma cancers.
Mesothelioma (or the cancer of the mesothelium) is a disease in which cells become abnormal and replicate without control. During Mesothelioma, these cells will invade and damage tissues and organs. Mesothelioma cancer cells can spread throughout the body causing death.
Mesothelioma treatments and Mesothelioma clinical trials and tests
There are many mesothelioma treatment options available. Treatments include surgery, radiation therapy and chemotherapy and the mesothelioma treatment depends on the patient’s age, general health and stage of the cancer. There has been much mesothelioma research conducted throughout the past two years to find new treatment methods. Click here to read more about mesothelioma treatment techniques.
Through mesothelioma research, The National Cancer Institute has sponsored mesothelioma tests and clinical trials that are designed to find new treatment methods. Because of the increase in number of mesothelioma cases in the United States, both governments have increased funding for mesothelioma research. Mesothelioma research and clinical trials have been successful in developing new techniques to fight this cancer and the outlook for more advanced mesothelioma treatments is promising.
Surgery is the most common treatment method for malignant mesothelioma. Tissues and linings affected by mesothelioma are removed by the doctor and may include the lung or even diaphragm.
A second mesothelioma treatment method is radiation therapy through the use of high energy x-rays that kill the cancer cells. Radiation therapy can be outside or inside the body.
A third mesothelioma treatment method is chemotherapy. Through pills or drugs through needles, chemotherapy drugs are used to kill cancer cells.
A new mesothelioma treatment method is called intraoperative photodynamic therapy. In this treatment, light and drugs are used to kill cancer cells during surgery for early stages of mesothelioma in the chest. Although there are numerous treatments and drugs for mesothelioma, doctors are losing the battle against this deadly disease. Most mesothelioma treatments involve old techniques combined with different drug cocktails. However, in most cases, these mesothelioma treatments have many side effects including organ damage, nausea, increase in heart failure etc. The rush to find a more effective mesothelioma treatment or even cure is ongoing at numerous clinical labs across the nation. Let's hope that the mesothelioma treatments will one day erradicate mesothelioma cancer and asbestosis.
With an abundance of information on the Internet, Mesothelioma Cancer and Asbestos has consolidated the most important issues surrounding Mesothelioma, Mesothelioma doctors and symptoms, Mesothelioma treatment, Mesothelioma research and tests.
At , the website contains useful resources on Mesothelioma lawyers and attorneys, as well as causes by asbestos exposure, asbestos removal, asbestos attorneys and lawsuits, and asbestos cancer. Patients stricken by Mesothelioma and their families require support and current information. Mesothelioma Online Resources hopes to educate and give hope to survivors and victims.
Mesothelioma is such a harsh disease. Not only does it take years for symptoms to appear, but there are limited treatements and drugs that will prolong the lives of workers stricken with mesothelioma. In many cases, the death rate of mesothelioma is unfortunately very high. However, with increased funding in mesothelioma research through the government and private grants, the outlook for a mesothelioma cure is quite possible. In the meantime, mesothelioma support groups and local discussions provide the ongoing support for mesothelioma patients.
Mesothelioma Cancer and Asbestos is your source for mesothelioma and asbestos information, treatments, clinical trials, attorneys, support groups and lawyers.
About the website: Michael Kenneth is a successful Internet Publisher and has researched and written on many topics for - your complete source for mesothelioma information, mesothelioma attorneys and lawyers, mesothelioma treatments and research, asbestos exposure and removal, asbestos attorneys and legislation as well as asbestos cancer.
Definition - Chemical peeling is a medical procedure which includes application of a chemical agent to the skin, causing controlled destruction of the epidermis, with or without the dermis, leading to exfoliation and removal of superficial lesions, followed by regeneration of new epidermal and dermal tissues.
In simple words chemical peeling or chemical rejuvenation is procedure where a chemical agent or combination of agents of defined strength are applied the skin causing a controlled destruction of layers of the skin. This is followed by regeneration and remodeling leading to improvement of texture and surface abnormalities. It is a safe, effective and affordable option for improving skin ageing and imperfections.
Skin Histology
Skin is considered the largest organ of the body and has many different functions. The skin is divided in two main regions, the epidermis and the dermis. The dermis is attached to an underlying hypodermis also called subcutaneous connective tissue.
Epidermis - It is the most superficial layer of the skin. The first barrier of protection from the invasion of foreign substances. The epidermis is divided into four layers - stratum corneum, stratum granulosum, stratum spinosum and stratum basalis (basal layer).
Dermis - It is composed of fibroblasts which are responsible for secreting collagen, elastin and ground substance that gives support and elasticity to skin. It supplies the epidermis with nutrients and has its role in thermoregulation. The dermis is subdivided into two zones, upper papillary and lower reticular layer.
Classification of peels according to histological depth
Very superficial peel - Exfoliation of the stratum cormeum, without any epidermal necrosis.
Superficial peel - Destruction of the full epidermis, up to the basal layer
Medium peel - Destruction of the epidermis, papillary dermis and up to the upper one third of the reticular dermis.
Deep peel - Necrosis of the entire epidermis and papillary dermis with inflammation extending to the mid reticular dermis.
Classification of chemical peeling agents
Very superficial Peel:
Glycolic Acid 30-50% applied for 1-2 minutes
TCA* 10% applied as one coat
Jessner's solution 1-3 coats
Superficial Peel:
Glycolic acid 50-70% applied for 2-10 mins (depending on the type and thickness of the skin)
TCA 10-30%
Jessner's solution 4-10 coats
Very superficial and superficial Peels are the mildest form and often called, "the lunchtime peel." These peels break down corneocyte adhesion, causing dead skin cells to shed off to reveal the fresh, healthy underlying skin. These peels address minor skin irregularities like discoloration, acne, surface scarring, fine lines, and sun spots.
Medium Peel:
Glycolic acid 70% applied for 3-30 mins (depending on the type and thickness of the skin)
TCA 35-50%
Glycolic Acid 70% plus TCA 35%
Jessner's solution plus TCA 35%
Deep Peel:
Phenol 88%
Baker Gordon phenol formula
Medium and deep peels increase the collagen and glycosaminoglycans content, cause collagen remodeling and increase dermal thickness to improve the clinical appearance of the skin with reduced wrinkles, skin tightening and pigmentary dyschromia.
Reason behind chemical peeling:
Wound healing process is an important reason for rejuvenation. The phases of wound healing after chemical exfoliation are apparent:
• Inflammatory phase (1-5 days) - This phase is evident after peeling as erythma and swelling on the skin
• Proliferative phase (2-21 days) - In superficial peels, the basement membrane is intact, hence normal epidermis is restored in 2 to 3 days. In medium to deep peels, wound is below basement membrane and re-epithelialization takes time.
• Remodeling phase (3 weeks to 2 years) - collagen remodeling is the main reason that chemical peels cause rejuvenation and reduce wrinkles.
Indications for peels:
1. Pigmentary disorders
a. Resistant melasma
b. Pigmented cosmetic dermatitis
c. Freckles
d. Lentigines
e. Post inflammatory hyperpigmentation
2. Acne
a. Comedonal acne
b. Post acne scars
c. Acne cosmetic
d. Acne excoriee
3. Cosmetic
a. Photoageing
b. Fine wrinkling
c. Skin glow and rejuvenation
d. Oily to rough skin
e. Actinic keratosis
4. Miscellaneous
a. Keratosis pilaris
b. Macular amyloidosis
c. Dilated pores
d. Seborrheic keratoses
Contraindications:
• Active bacterial, viral and fungal infection and open wounds
• Oral isotretinoin use within the past three months
• Pregnancy and breast feeding
• History of keloid formation
• History of taking oral contraceptive and photosensitive drugs
• Unrealistic patient expectation
• Uncooperative patient, eg. Patient is careless about sun exposure or application of medicine
• For medium depth and deep peels, history of abnormal scarring, atrophic skin and isotretinoin use in the last six months.
How to choose a patient:
A patient should be chosen depending upon 4P's:
P - Pathology
P - Point of depth required
P - Patients skin
P - Previous peeling agents
Newer peels:
Many peels like mandelic acid, kojic acid, lactic acid, citric acid and many more have been introduced in the market which are also available in combination. These peels are not only more skin friendly but also more patient friendly. They have buffering agents like licorice extract and willow bark extract to minimize irritation to skin and antioxidants to infuse the skin with restorative nutrients. The change in the skin often occurs at cellular level and are not apparent to the naked hence making it more popular amongst busy patients who are seeking effective treatments quickly with little or no downtime.
Benefits of chemical peels:
• The skin becomes noticeably smoother and rejuvenated.
• It reduces pigmentation, improves dull and uneven skin tone, reduces signs of photoagaeing, acne and enlarged pores.
• Removes dead and damaged skin cells and improves skin texture
• Helps in removal of tan
• Skin becomes brighter and more vivid because chemical peels not only cause re-epithelialization of the epidermis but also collagen remodeling.
Pre peel and post peel precautions:
• Patient has to be motivated enough to get multiple sittings of the peel ( 4-8, depending on the indication and type of peel) every 2-3 weekly to get the desired result.
• Patient should not wax, bleach, scrub, shave(the same day) or get any other aesthetic procedure like microdermabrasion, ipl, derma-roller one day before the chemical peel procedure. A gap of atleast 7 days before and after the peel should be maintained.
• Patient should use a mild soap/ non soap cleanser after the peel
• Broad spectrum sunscreen and moisturizer should be used liberally, atleast 2-3 times a day and sun exposure should be avoided.
• Patient should be strictly prohibited from scratching, picking or scrubbing the skin.
Take home message:
Chemical peeling is a simple office procedure for the treatment of acne, pigmentation, skin rejuvenation and photoageing. These are not one time procedures but require 6-8 sessions and maintenance peels to achieve maximum improvement and prevent recurrences. The newer peels are safer and effective.
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